Usually , clr is binding to c1inh ( cl inhibitor ) . when immune complex ( ic ) binds to clq , c1inh is detached form clr , and then the serine protease is activated , and then the complement classical pathway is activated 在一般情况下, c1r与c1inh ( c1inhibitor )结合着,而一旦有免疫复合物( ic )结合到c1q上时,浙江大学硕士学位论文cllnh的抑制作用即行移除, clr的构象发生改变,具有酶活性,从而启动补体激活经典途径。